I mentioned Skyrim recently, but here's a better list of some upcoming games I'm looking forward to this year and why.
The Elder Scrolls V: Skyrim
Anyone who's played Morrowind of Oblivion should know what a big deal this is going to be. A huge, open world Elder Scrolls game from Bethesda, for fans of the series that's all you really need to say. If you aren't already a fan of the series, I'd suggest you read up on Skyrim and watch some more footage. This is likely to be the biggest game of this year and likely the years to come... until The Elder Scrolls VI is released, anyway.
Batman: Arkham City
If you've played Batman: Arkham Asylum then you've probably already played this or at least have it pre-ordered. This game has been out for a little while now on Xbox 360 and PS3 but I'll be playing the PC version when it releases on 11/15. This is, without a doubt, the best Batman game in existence. In fact, it's been called the best use of a license in video game history. This doesn't surprise me at all considering the last one, Arkham Asylum, was such an amazing game. If you haven't played that one, I highly suggest that you do. If you thought a GOOD superhero/licensed game wasn't possible, it will make your year. There are demos for the console and PC versions of Arkham Asylum, so give it a shot.
Saints Row: The Third
I was a fan of the original Saints Row on Xbox 360 and Saints Row 2. Although I didn't play much of the second one as it had real ads in it, I returned it to Gamestop when I saw the first one. I've gotten official confirmation from two different sources that Saints Row The Third has no real ads in it, so this one is a must buy for me. If you're a fan of Saints Row already, you know that this will likely be fifteen different kinds of awesome. If you aren't already a fan, think Grand Theft Auto on some kind of hallucinogenic drug. It's completely off-the-rails wacky fun. Just visit youtube and watch more footage if you don't know what I'm talking about. This one should be a riot.
There are plenty of other good ones this year, but these are my top 3.
L.A. Noire (PC version)
Guild Wars 2